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Target
NAD(+) hydrolase SARM1
Ligand
BDBM50166940
Substrate
n/a
Meas. Tech.
n Vitro Biochemical Test of Inhibiting SARM1 Enzyme Activity Assay
IC50
<1000±n/a nM
Citation
 NIU, D; ZHU, Z; ZHAO, Y; LI, W SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES US Patent  US20230414581 Publication Date 12/28/2023 
Target
Name:
NAD(+) hydrolase SARM1
Synonyms:
3.2.2.- | 3.2.2.6 | HsTIR | KIAA0524 | MyD88-5 | NAD(+) hydrolase SARM1 | NADP(+) hydrolase SARM1 | NADase SARM1 | SAM domain-containing protein 2 | SAMD2 | SAMD2 GN | SARM | SARM1 | SARM1_HUMAN | Sterile alpha and Armadillo repeat protein | Sterile alpha and TIR motif-containing protein 1 | Sterile alpha motif domain-containing protein 2 | Synonyms=KIAA0524 | Tir-1 homolog | hSARM1
Type:
PROTEIN
Mol. Mass.:
79387.31
Organism:
Human
Description:
ChEMBL_119100
Residue:
724
Sequence:
MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
  
Inhibitor
Name:
BDBM50166940
Synonyms:
NP-031112 | NP-12 | Tideglusib | US20230414581, Compound 7 | med.21724, Compound 155
Type:
Small organic molecule
Emp. Form.:
C19H14N2O2S
Mol. Mass.:
334.392
SMILES:
O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
Structure:
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