Reaction Details Report a problem with these data
Target
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238]
Ligand
BDBM646355
Substrate
n/a
Meas. Tech.
In Vitro Enzymatic Activity Assay on WRN Helicase
IC50
70.0±n/a nM
Citation
Bordas, V; Brun, J; Furegati, M; Hamon, J; Hinrichs, JH; Holzer, P; Limam, F; Möbitz, H; Nocito, S; Plattner, S; Schmiedeberg, N; Schoepfer, J; Strang, RS; Zecri, F Bicyclic compounds and their uses US Patent US11878973 Publication Date 1/23/2024
More Info.:
Target
Name:
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238]
Synonyms:
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (517-1238)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81717.91
Organism:
Homo sapiens (Human)
Description:
Q14191[517-1238]
Residue:
722
Sequence:
NEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKP