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Target
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
Ligand
BDBM648851
Substrate
n/a
Meas. Tech.
CDK1/Cyclin B1 ADP-Glo Kinase Assay
IC50
1.000±n/a nM
Citation
 VERNIER, W; NGUYEN, QN; REZAYEE, N; GOMEZ, L; ZHANG, C; MILLER, III, TF; MANBY, FR AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE US Patent  US20240034731 Publication Date 2/1/2024 
Target
Name:
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
Synonyms:
CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components.
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Component 2
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB | CCNB1 | CCNB1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
48340.95
Organism:
Homo sapiens (Human)
Description:
P14635
Residue:
433
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
  
Inhibitor
Name:
BDBM648851
Synonyms:
8-(1,1-difluoro-5-azaspiro[2.4]heptan-5-yl)-N- ((1s,4s)-4-((dimethylamino)methyl)cyclohexyl)-6- methylpyrido[3,4-d]pyrimidin-2-amine | US20240034731, Compound 45
Type:
Small organic molecule
Emp. Form.:
C23H32F2N6
Mol. Mass.:
430.5372
SMILES:
CN(C)C[C@H]1CC[C@H](CC1)Nc1ncc2cc(C)nc(N3CCC4(CC4(F)F)C3)c2n1 |r,wU:7.10,4.3,(-8.46,-4.26,;-7.13,-3.49,;-7.13,-1.95,;-5.79,-4.26,;-4.46,-3.49,;-4.46,-1.95,;-3.13,-1.18,;-1.79,-1.95,;-1.79,-3.49,;-3.13,-4.26,;-.46,-1.18,;.88,-1.95,;.88,-3.49,;2.21,-4.26,;3.54,-3.49,;4.88,-4.26,;6.21,-3.49,;7.54,-4.26,;6.21,-1.95,;4.88,-1.18,;4.88,.36,;3.63,1.26,;4.11,2.73,;5.65,2.73,;5.81,4.26,;7.05,3.36,;8.3,2.45,;8.46,3.98,;6.12,1.26,;3.54,-1.95,;2.21,-1.18,)|
Structure:
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