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Target
Proteasome subunit beta type-8
Ligand
BDBM651191
Substrate
n/a
Meas. Tech.
IC50 Determination
IC50
68.0±n/a nM
Citation
 LIN, G; NATHAN, C; KIRKMAN, L; ZHAN, W; MORGAN, T; SATO, K; HARA, R; KAWASAKI, M; IMAEDA, T; TOITA, A; OKAMOTO, R; YUKAWA, T; ASO, K; WONG, T; GINN, JD; FOLEY, MA MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS US Patent  US20240043470 Publication Date 2/8/2024 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM651191
Synonyms:
US20240043470, Compound 3-46-A | US20240043470, Compound 3-46-B
Type:
Small organic molecule
Emp. Form.:
C33H41FN4O5
Mol. Mass.:
592.7008
SMILES:
Fc1ccccc1CNC(=O)[C@@H]1CCCCOc2cccc(CCC(=O)N[C@@H](CC(=O)N3CCCC3C3CC3)C(=O)N1)c2 |r|
Structure:
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