Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM614683
Substrate
n/a
Meas. Tech.
Calcium Flux Assays (hB1 IC50 IMR90)
IC50
3.70±n/a nM
Citation
BAEURLE, S; DAVENPORT, A; STIMSON, C; NAGEL, J; SCHMIDT, N; ROTGERI, A; GROETICKE, I; RAUSCH, A; KLAR, J; DYRKS, T CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR US Patent US20230271931 Publication Date 8/31/2023
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM614683
Synonyms:
5-({[1-(4- Chloro-2- fluorophenyl) cyclopropyl] carbonyl}amino)- 2-(1- cyclobutyl-1H- pyrazol-4-yl)-3- fluorobenzoic | US20230271931, Example 41
Type:
Small organic molecule
Emp. Form.:
C24H20ClF2N3O3
Mol. Mass.:
471.884
SMILES:
OC(=O)c1cc(NC(=O)C2(CC2)c2ccc(Cl)cc2F)cc(F)c1-c1cnn(c1)C1CCC1