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Target
D(1A) dopamine receptor
Ligand
BDBM337363
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
76.8±n/a nM
Citation
 Gray, DL; Zhang, L; Brodney, MA; Davoren, JE; Efremov, IV; Green, ME; O Neil, SV; Rogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent  US9745317 Publication Date 8/29/2017 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM337363
Synonyms:
4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]-2,3-dihydrofuro[3,2-c]pyridine (1) | US9745317, 1
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2
Mol. Mass.:
333.3838
SMILES:
Cc1cc(Oc2nccc3OCCc23)ccc1-c1c(C)ncnc1C |(-13.7,-3.62,;-13.7,-5.16,;-15.03,-5.93,;-15.03,-7.47,;-16.36,-8.24,;-16.36,-9.78,;-15.03,-10.55,;-15.03,-12.09,;-16.36,-12.86,;-17.7,-12.09,;-19.16,-12.57,;-20.07,-11.32,;-19.16,-10.08,;-17.7,-10.55,;-13.7,-8.24,;-12.36,-7.47,;-12.36,-5.93,;-11.03,-5.16,;-9.7,-5.93,;-9.7,-7.47,;-8.36,-5.16,;-8.36,-3.62,;-9.7,-2.85,;-11.03,-3.62,;-12.36,-2.85,)|
Structure:
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