Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM337388
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
162±n/a nM
Citation
 Gray, DL; Zhang, L; Brodney, MA; Davoren, JE; Efremov, IV; Green, ME; O Neil, SV; Rogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent  US9745317 Publication Date 8/29/2017 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM337388
Synonyms:
US9745317, 26
Type:
Small organic molecule
Emp. Form.:
C20H16N4O3
Mol. Mass.:
360.366
SMILES:
Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3OCCc23)cc1C#N |(4.52,-.38,;4.52,1.16,;5.85,1.93,;5.85,3.47,;4.52,4.23,;4.52,5.78,;3.19,3.47,;1.85,4.24,;3.19,1.93,;1.85,1.15,;1.85,-.38,;.52,-1.15,;-.82,-.38,;-2.15,-1.15,;-2.15,-2.69,;-.82,-3.47,;-.82,-5,;-2.15,-5.78,;-3.48,-5,;-4.95,-5.48,;-5.85,-4.23,;-4.95,-2.99,;-3.48,-3.47,;-.82,1.15,;.52,1.98,;.52,3.52,;.52,5.06,)|
Structure:
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