Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 4
Ligand
BDBM345279
Substrate
n/a
Meas. Tech.
Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells
IC50
33.0±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345279
Synonyms:
2-[[1-[(2-Chlorophenyl)methyl]-5-(2- thienyl)pyrazol-3-yl]methoxy]-2-methyl- propanoic acid. 1HNMR (CDCl3): $#948; 1.37 (s, 6H), 4.39 (s, 2H), 5.47 (s, 2H), 6.53 (s, 1H), 6.59-6.61 (m, 1H), 7.09-7.14 (m, 2H), 7.24-7.31 (m, 2H), 7.45-7.47 (m, 1H), 7.62-7.64 (m, 1H). | US10202350, Example 25 | US10214492, Example 25 | US11292767, Example 25 | US11724989, Example 25
Type:
Small organic molecule
Emp. Form.:
C19H19ClN2O3S
Mol. Mass.:
390.884
SMILES:
CC(C)(OCc1cc(-c2cccs2)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
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