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Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM345308
Substrate
n/a
Meas. Tech.
Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells
IC50
27000±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Human
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM345308
Synonyms:
2-({1-[(o-Chlorophenyl)methyl]-5-(m- methoxyphenyl)-4-methyl-1H-pyrazol-3- yl}methoxy)-2-methylpropionic acid 1H-NMR: (300 MHz, MeOD) $#948; 1.53 (6 H, s), 2.09 (3 H, s), 3.67 (3 H, s), 4.60 (2 H, s), 5.31 (2 H, s), 6.67-6.86 (3 H, m), 6.97 (1 H, ddd), 7.17-7.40 (4 H, m). | US10202350, Example 54 | US10214492, Example 54 | US11292767, Example 54 | US11724989, Example 54
Type:
Small organic molecule
Emp. Form.:
C23H25ClN2O4
Mol. Mass.:
428.909
SMILES:
COc1cccc(c1)-c1c(C)c(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
Structure:
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