Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 4
Ligand
BDBM345321
Substrate
n/a
Meas. Tech.
Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells
IC50
11.0±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345321
Synonyms:
2-([1-(o-Chlorophenyl)methyl]-5-(m-methoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-ethylbutyric Acid | US10202350, Example 67 | US10214492, Example 67 | US11292767, Example 67 | US11724989, Example 67
Type:
Small organic molecule
Emp. Form.:
C24H27ClN2O4
Mol. Mass.:
442.935
SMILES:
CCC(CC)(OCc1cc(-c2cccc(OC)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: