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Target
Monocarboxylate transporter 4
Ligand
BDBM345332
Substrate
n/a
Meas. Tech.
Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells
IC50
59.0±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345332
Synonyms:
2-[[1-[(2-Chlorophenyl)methyl]-5-(3-hydroxyphenyl)pyrazol-3-yl]methoxy]-2-methyl-propanoic Acid | US10202350, Example 79 | US10214492, Example 79 | US11292767, Example 79 | US11724989, Example 79
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O4
Mol. Mass.:
400.855
SMILES:
CC(C)(OCc1cc(-c2cccc(O)c2)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
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