Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM360646
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
106±n/a nM
Citation
 Cecere, G; Galley, G; Norcross, R; Patiny-Adam, A; Pflieger, P Substituted pyrazino[2,2-a]isoquinoline derivatives US Patent  US9828374 Publication Date 11/28/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_MOUSE | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Protein
Mol. Mass.:
37635.41
Organism:
Mus musculus (Mouse)
Description:
Q923Y8
Residue:
332
Sequence:
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM360646
Synonyms:
(11bR)-N-(5-cyclopropylpyrimidin-2-yl)-8-fluoro-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-amine | US9828374, Example 33
Type:
Small organic molecule
Emp. Form.:
C19H22FN5
Mol. Mass.:
339.4099
SMILES:
Fc1c(Nc2ncc(cn2)C2CC2)ccc2[C@@H]3CNCCN3CCc12 |r|
Structure:
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