Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM360654
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
145±n/a nM
Citation
 Cecere, G; Galley, G; Norcross, R; Patiny-Adam, A; Pflieger, P Substituted pyrazino[2,2-a]isoquinoline derivatives US Patent  US9828374 Publication Date 11/28/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM360654
Synonyms:
(R)-3-ethyl-N-(2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl)-4-methyl-1H-pyrazole-5-carboxamide | US9828374, Example 41
Type:
Small organic molecule
Emp. Form.:
C19H25N5O
Mol. Mass.:
339.4347
SMILES:
CCc1n[nH]c(C(=O)Nc2ccc3[C@@H]4CNCCN4CCc3c2)c1C |r|
Structure:
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