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Target
Tyrosine-protein kinase SYK
Ligand
BDBM243362
Substrate
n/a
Meas. Tech.
In Vitro SYK Inhibition Assay
pH
7.8±n/a
Temperature
298.15±n/a K
IC50
<500±n/a nM
Comments
extracted
Citation
 Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent  US10053455 Publication Date 8/21/2018 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM243362
Synonyms:
4-{5-[2-Fluoro-5-(4- methyl-pyrimidin-2- ylamino)-phenyl]-oxazol- 2-yl}-4,7-diaza- spiro[2.5]octan-8-one | US10053455, 018
Type:
Small organic molecule
Emp. Form.:
C20H19FN6O2
Mol. Mass.:
394.4023
SMILES:
Cc1ccnc(Nc2ccc(F)c(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1
Structure:
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