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Target
Nuclear receptor ROR-gamma
Ligand
BDBM363756
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
16.2±n/a nM
Citation
 Khairatkar-Joshi, N; Kulkarni, A; Shah, DM; Bhosale, VM; Lodhiya, BJ; Thiraviam, AM; Marathe, M; Hadambar, AA Treatment of respiratory disorders using ROR-gamma inhibitors US Patent  US9855229 Publication Date 1/2/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM363756
Synonyms:
US9855229, Compound 10
Type:
Small organic molecule
Emp. Form.:
C27H26Cl2FNO5S
Mol. Mass.:
566.468
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(OC3(CCOCC3)c3ccc(Cl)cc3Cl)c(F)c2)cc1
Structure:
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