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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM370466
Substrate
n/a
Meas. Tech.
Enzymatic IDO Assay
IC50
550±n/a nM
Citation
 Mautino, M; Kumar, S; Waldo, J; Jaipuri, F; Kesharwani, T; Zhang, X IDO inhibitors US Patent  US10233190 Publication Date 3/19/2019 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM370466
Synonyms:
2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1- (1,4-dioxaspiro[4.5]decan-8-yl)ethanol; | US10233190, Example 1378
Type:
Small organic molecule
Emp. Form.:
C20H23FN2O3
Mol. Mass.:
358.4066
SMILES:
OC(CC1c2c(cccc2F)-c2cncn12)C1CCC2(CC1)OCCO2
Structure:
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