Reaction Details Report a problem with these data
Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM22294
Substrate
BDBM22231
Meas. Tech.
Enzyme Inhibition Assay
IC50
>10000±n/a nM
Citation
Weinstein, DS; Liu, W; Gu, Z; Langevine, C; Ngu, K; Fadnis, L; Combs, DW; Sitkoff, D; Ahmad, S; Zhuang, S; Chen, X; Wang, FL; Loughney, DA; Atwal, KS; Zahler, R; Macor, JE; Madsen, CS; Murugesan, N Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase. Bioorg Med Chem Lett 15:1435-40 (2005) [PubMed] Article
More Info.:
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase
Type:
Enzyme
Mol. Mass.:
75309.71
Organism:
Oryctolagus cuniculus (rabbit)
Description:
15-LO enzyme was purified from phenylhydrazine treated rabbits.
Residue:
663
Sequence:
MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLAWGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRDQPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI
Inhibitor
Name:
BDBM22294
Synonyms:
4-({2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}sulfamoyl)benzoic acid | tryptamine sulfonamide, 37d
Type:
Small organic molecule
Emp. Form.:
C24H22N2O5S
Mol. Mass.:
450.507
SMILES:
COc1ccc(cc1)-c1[nH]c2ccccc2c1CCNS(=O)(=O)c1ccc(cc1)C(O)=O