Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [182-426]
Ligand
BDBM373545
Substrate
n/a
Meas. Tech.
PHD enzymatic assay
IC50
63.1±n/a nM
Citation
Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors US Patent US10246442 Publication Date 4/2/2019
More Info.:
Target
Name:
Egl nine homolog 1 [182-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | HIF-1alpha-PHD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27392.37
Organism:
Human
Description:
Q9GZT9[182-426]
Residue:
245
Sequence:
NGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
Inhibitor
Name:
BDBM373545
Synonyms:
1-[4-(2-Chloro-phenylamino)-6-(2,6-dimethyl-phenoxy)-7-fluoro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid; | US10246442, Example 7 | US10975062, Example 7
Type:
Small organic molecule
Emp. Form.:
C26H19ClFN5O3
Mol. Mass.:
503.912
SMILES:
Cc1cccc(C)c1Oc1cc2c(Nc3ccccc3Cl)nc(nc2cc1F)-n1cc(cn1)C(O)=O