Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [182-426]
Ligand
BDBM373668
Substrate
n/a
Meas. Tech.
PHD enzymatic assay
IC50
31.6±n/a nM
Citation
Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors US Patent US10246442 Publication Date 4/2/2019
More Info.:
Target
Name:
Egl nine homolog 1 [182-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | HIF-1alpha-PHD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27392.37
Organism:
Human
Description:
Q9GZT9[182-426]
Residue:
245
Sequence:
NGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
Inhibitor
Name:
BDBM373668
Synonyms:
1-(6-(Cyclohexyloxy)-4-(diethylamino)-7-chloroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid; | US10246442, Example 138 | US10975062, Example 138
Type:
Small organic molecule
Emp. Form.:
C22H26ClN5O3
Mol. Mass.:
443.927
SMILES:
CCN(CC)c1nc(nc2cc(Cl)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O