Reaction Details Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src [1-530]
Ligand
BDBM378889
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assays
IC50
4.00±n/a nM
Citation
 Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent  US10266537 Publication Date 4/23/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [1-530]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src (aa 1-530) | SRC | SRC1 | SRC_HUMAN | c-Src (aa 1-530)
Type:
n/a
Mol. Mass.:
59200.93
Organism:
Human
Description:
P12931[1-530]
Residue:
530
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY
  
Inhibitor
Name:
BDBM378889
Synonyms:
Preparation of N-(3-((4-amino-1-isopropyl-1H-pyrazolo [3,4-d] pyrimidin-3-yl) ethynyl)-4-methylphenyl)-4-(4-methylpiperazin-1-yl) methyl) benzamide | US10266537, Compound 1
Type:
Small organic molecule
Emp. Form.:
C30H34N8O
Mol. Mass.:
522.644
SMILES:
CC(C)n1nc(C#Cc2cc(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)ccc2C)c2c(N)ncnc12
Structure:
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