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Target
Beta-2 adrenergic receptor
Ligand
BDBM25399
Substrate
BDBM25393
Meas. Tech.
beta2 Adrenergic Receptor Binding Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
2296±355 nM
Citation
 Karellas, P; McNaughton, M; Baker, SP; Scammells, PJ Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. J Med Chem 51:6128-37 (2008) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM25399
Synonyms:
Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}-12-hydroxy-4,7-dioxa-1,10-diazadodecan-12-yl)-2-hydroxyphenyl]formamide
Type:
Small organic molecule
Emp. Form.:
C25H35N7O9
Mol. Mass.:
577.5869
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCOCCOCCNCC(O)c3ccc(O)c(NC=O)c3)ncnc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25393
Synonyms:
3-iodopindolol | [(2S)-2-hydroxy-3-[(3-iodo-1H-indol-4-yl)oxy]propyl](propan-2-yl)amine | [125I]-(-)iodopindolol
Type:
radiolabeled ligand
Emp. Form.:
C14H19IN2O2
Mol. Mass.:
374.2173
SMILES:
CC(C)NC[C@H](O)COc1cccc2[nH]cc(I)c12
Structure:
Search PDB for entries with ligand similarity: