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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384623
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
12.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384623
Synonyms:
4-{[trans-4-(4,4- difluoroazepan-1- yl)cyclohexyl]amino} quinazoline-6-carbonitrile | US9932350, 3-53
Type:
Small organic molecule
Emp. Form.:
C21H25F2N5
Mol. Mass.:
385.4535
SMILES:
FC1(F)CCCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:12.16,wD:9.9,(2.04,-8.07,;3.37,-7.3,;4.7,-8.07,;4.76,-6.64,;5.1,-5.13,;4.14,-3.93,;2.6,-3.93,;1.64,-5.13,;1.98,-6.64,;1.83,-2.6,;2.6,-1.26,;1.83,.07,;.29,.07,;-.48,-1.26,;.29,-2.6,;-.48,1.41,;-2.02,1.41,;-2.79,.07,;-4.33,.07,;-5.1,1.41,;-4.33,2.74,;-5.1,4.07,;-4.33,5.41,;-2.79,5.41,;-2.02,4.07,;-2.79,2.74,;-2.02,6.74,;-1.25,8.07,)|
Structure:
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