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Target
Store-operated calcium entry-associated regulatory factor
Ligand
BDBM387277
Substrate
n/a
Meas. Tech.
SOCE inhibition
IC50
<1000±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Store-operated calcium entry-associated regulatory factor
Synonyms:
HBV X-transactivated gene 3 protein | HBV XAg-transactivated protein 3 | Protein FOAP-7 | SARAF | SOCE-associated regulatory factor | TMEM66 | Transmembrane protein 66 | XTP3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36978.81
Organism:
Homo sapiens (Human)
Description:
Q96BY9
Residue:
339
Sequence:
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
  
Inhibitor
Name:
BDBM387277
Synonyms:
N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2-methoxy- phenyl)thiophene- 2-carboxamide | US10292981, Example 160
Type:
Small organic molecule
Emp. Form.:
C23H18F2N2O4S
Mol. Mass.:
456.462
SMILES:
COc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O |t:27|
Structure:
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