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Target
Tyrosine-protein kinase BTK
Ligand
BDBM389998
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
505±n/a nM
Citation
 Liu, D; Zhang, M; Hu, Q Aminopyridazinone compounds as protein kinase inhibitors US Patent  US9951077 Publication Date 4/24/2018 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Human
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM389998
Synonyms:
US10323037, Example 15 | US9951077, 15
Type:
Small organic molecule
Emp. Form.:
C29H29N5O3
Mol. Mass.:
495.5723
SMILES:
Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CC2CCC(C1)C2NC(=O)C=C |TLB:7:24:27.28:31,(1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;1.33,2.31,;1.33,3.85,;,1.54,;-1.46,2.02,;-2.37,.77,;-1.46,-.48,;-1.94,-1.94,;-.91,-3.09,;-1.39,-4.55,;-2.89,-4.87,;-3.37,-6.33,;-4.87,-6.65,;-5.35,-8.12,;-6.86,-8.44,;-7.89,-7.29,;-7.41,-5.83,;-5.91,-5.51,;-3.92,-3.73,;-3.45,-2.26,;;-1.94,3.48,;-1.88,5.03,;-3.58,5.36,;-4.44,4.19,;-5.72,3.74,;-4.49,4.84,;-2.72,4.46,;-4.43,6.38,;-4.93,7.83,;-6.44,8.13,;-7.46,6.97,;-6.94,9.59,;-8.45,9.89,)|
Structure:
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