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Target
Histone deacetylase
Ligand
BDBM19130
Substrate
pfHDAC-1 Substrate
Meas. Tech.
pfHDAC-1 Enzyme Assay
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
0.6±0.1 nM
Km
30000±2000 nM
kcat
0.19±0.01 1/sec
Citation
Patel, V; Mazitschek, R; Coleman, B; Nguyen, C; Urgaonkar, S; Cortese, J; Barker, RH; Greenberg, E; Tang, W; Bradner, JE; Schreiber, SL; Duraisingh, MT; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem 52:2185-7 (2009) [PubMed] Article
Target
Name:
Histone deacetylase
Synonyms:
Histone Deacetylase (pfHDAC-1)
Type:
Enzyme
Mol. Mass.:
51371.91
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells.
Residue:
449
Sequence:
MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNELTLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGASKLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLSRIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKEHSTTHHLRRKNYDDDFFDLSDRDQSIVPY
Inhibitor
Name:
BDBM19130
Synonyms:
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | CHEMBL99 | TSA | Trichostatin A (TSA)
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Substrate
Name:
pfHDAC-1 Substrate
Synonyms:
n/a
Type:
fluorogenic, acetylated peptide
Mol. Mass.:
1609.93
Organism:
n/a
Description:
n/a
Residue:
15
Sequence:
ACLEGLYLYSACAMC