Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33073
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
5200±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33073
Synonyms:
2-Amino-4-(4-fluoro-phenyl)-6-(5-methyl-furan-2-yl)-nicotinonitrile | 2-amino-4-(4-fluorophenyl)-6-(5-methyl-2-furanyl)-3-pyridinecarbonitrile | 2-amino-4-(4-fluorophenyl)-6-(5-methyl-2-furyl)nicotinonitrile | 2-amino-4-(4-fluorophenyl)-6-(5-methylfuran-2-yl)pyridine-3-carbonitrile | 2-azanyl-4-(4-fluorophenyl)-6-(5-methylfuran-2-yl)pyridine-3-carbonitrile | MLS000555018 | SMR000147135 | cid_705445
Type:
Small organic molecule
Emp. Form.:
C17H12FN3O
Mol. Mass.:
293.2951
SMILES:
Cc1ccc(o1)-c1cc(-c2ccc(F)cc2)c(C#N)c(N)n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR