Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM820
Substrate
n/a
Meas. Tech.
Protease Inhibition Assay
IC50
0.500000±n/a nM
Citation
Munroe, JE; Shepherd, TA; Jungheim, LN; Hornback, WJ; Hatch, SD; Muesing, MA; Wiskerchen, M; Su, KS; Campanale, KM; Baxter, AJ; Colacino, JM Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids Bioorg Med Chem Lett 5:2897-902 (1995)
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM820
Synonyms:
(3aR,6S,7aS)-N-tert-butyl-5-[(2R,3S)-3-[(2S)-2-acetamido-3-(naphthalene-2-sulfonyl)propanamido]-2-hydroxy-4-phenylbutyl]-octahydrothieno[3,2-c]pyridine-6-carboxamide | Saquinavir/Nelfinavir deriv. 24
Type:
Small organic molecule
Emp. Form.:
C37H48N4O6S2
Mol. Mass.:
708.93
SMILES:
[H][C@]12CCS[C@@]1([H])C[C@H](N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CS(=O)(=O)c1ccc3ccccc3c1)NC(C)=O)C2)C(=O)NC(C)(C)C |r|