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Target
GTPase KRas [1-37]
Ligand
BDBM43248
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype
EC50
33610±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Human
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
  
Inhibitor
Name:
BDBM43248
Synonyms:
(5Z)-5-[(2E)-2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2-ylidene)ethylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(2E)-2-(3-ethyl-4,5-diphenyl-2-thiazolylidene)ethylidene]-3-methyl-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[(2E)-2-(3-ethyl-4,5-diphenyl-4-thiazolin-2-ylidene)ethylidene]-3-methyl-2-thioxo-thiazolidin-4-one | 5-[2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2(3H)-ylidene)ethylidene]-3-methyl-2-thioxo-1,3-thiazolidin-4-one | MLS000547610 | SMR000114403 | cid_1588252
Type:
Small organic molecule
Emp. Form.:
C23H20N2OS3
Mol. Mass.:
436.613
SMILES:
CCN1\C(SC(=C1c1ccccc1)c1ccccc1)=C/C=C1\SC(=S)N(C)C1=O |c:5|
Structure:
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