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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43342
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
1670±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43342
Synonyms:
2-(5-Acetylamino-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-ylsulfanyl)-N-(1-phenyl-ethyl)-acetamide | 2-[(5-acetamido-4,6-diketo-1H-pyrimidin-2-yl)thio]-N-(1-phenylethyl)acetamide | 2-[(5-acetamido-4,6-dioxo-1H-pyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)acetamide | 2-[(5-acetamido-4,6-dioxo-1H-pyrimidin-2-yl)thio]-N-(1-phenylethyl)acetamide | 2-[[5-acetamido-4,6-bis(oxidanylidene)-1H-pyrimidin-2-yl]sulfanyl]-N-(1-phenylethyl)ethanamide | MLS000072139 | SMR000011589 | cid_646513
Type:
Small organic molecule
Emp. Form.:
C16H18N4O4S
Mol. Mass.:
362.404
SMILES:
CC(NC(=O)CSc1nc(O)c(NC(C)=O)c(=O)[nH]1)c1ccccc1
Structure:
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