Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4
Ligand
BDBM43212
Substrate
n/a
Meas. Tech.
Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists
IC50
5080±n/a nM
Citation
 PubChem, PC Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists PubChem Bioassay (2008)[AID] 
Target
Name:
Ephrin type-A receptor 4
Synonyms:
EPHA4_MOUSE | Eph receptor A4 | Epha4 | Sek | Sek1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109812.17
Organism:
Mouse
Description:
gi_34328113
Residue:
986
Sequence:
MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
  
Inhibitor
Name:
BDBM43212
Synonyms:
(5Z)-5-[(2Z)-2-(1-ethyl-3,3-dimethyl-2-indolylidene)ethylidene]-3-propyl-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[(2Z)-2-(1-ethyl-3,3-dimethyl-indol-2-ylidene)ethylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(2Z)-2-(1-ethyl-3,3-dimethyl-indolin-2-ylidene)ethylidene]-3-propyl-2-thioxo-thiazolidin-4-one | (5Z)-5-[(2Z)-2-(1-ethyl-3,3-dimethylindol-2-ylidene)ethylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one | 5-[2-(1-ethyl-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene)ethylidene]-3-propyl-2-thioxo-1,3-thiazolidin-4-one | MLS000544534 | SMR000163634 | cid_11948835
Type:
Small organic molecule
Emp. Form.:
C20H24N2OS2
Mol. Mass.:
372.547
SMILES:
CCCN1C(=S)S\C(=C/C=C2\N(CC)c3ccccc3C2(C)C)C1=O
Structure:
Search PDB for entries with ligand similarity: