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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM32285
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein.
EC50
1070±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM32285
Synonyms:
(4E)-2-methoxy-4-[([1,2,4]triazolo[3,4-a]phthalazin-6-ylhydrazo)methylidene]-1-cyclohexa-2,5-dienone | (4E)-2-methoxy-4-[[2-([1,2,4]triazolo[3,4-a]phthalazin-6-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | (4E)-2-methoxy-4-[[N'-([1,2,4]triazolo[3,4-a]phthalazin-6-yl)hydrazino]methylene]cyclohexa-2,5-dien-1-one | MLS000521522 | SMR000131930 | cid_11957199
Type:
Small organic molecule
Emp. Form.:
C17H14N6O2
Mol. Mass.:
334.3321
SMILES:
COc1cc(CN=Nc2nn3cnnc3c3ccccc23)ccc1O |w:7.7|
Structure:
Search PDB for entries with ligand similarity: