Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM37480
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM37480
Synonyms:
5-ethyl-2-(pyrrolidine-1-carbonyl)thieno[3,2-c]quinolin-4-one | 5-ethyl-2-[oxo(1-pyrrolidinyl)methyl]-4-thieno[3,2-c]quinolinone | 5-ethyl-2-pyrrolidin-1-ylcarbonyl-thieno[3,2-c]quinolin-4-one | MLS000118145 | SMR000095093 | cid_5309331
Type:
Small organic molecule
Emp. Form.:
C18H18N2O2S
Mol. Mass.:
326.413
SMILES:
CCn1c2ccccc2c2sc(cc2c1=O)C(=O)N1CCCC1
Structure:
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