Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43509
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
31790±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43509
Synonyms:
2-mesyl-4-(2-methoxyphenyl)-6-(trifluoromethyl)pyrimidine | 4-(2-methoxyphenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine | MLS000519881 | SMR000130296 | US11725000, Compound 51 | cid_4655086
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2O3S
Mol. Mass.:
332.298
SMILES:
COc1ccccc1-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Structure:
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