Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43511
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43511
Synonyms:
2-[[(5-methyl-2-phenyl-3-pyrazolyl)amino]methylidene]propanedioic acid diethyl ester | 2-[[(5-methyl-2-phenyl-pyrazol-3-yl)amino]methylene]malonic acid diethyl ester | MLS000520937 | SMR000131346 | cid_4073731 | diethyl 2-[[(5-methyl-2-phenyl-pyrazol-3-yl)amino]methylidene]propanedioate | diethyl 2-[[(5-methyl-2-phenylpyrazol-3-yl)amino]methylidene]propanedioate
Type:
Small organic molecule
Emp. Form.:
C18H21N3O4
Mol. Mass.:
343.377
SMILES:
CCOC(=O)C(C=Nc1cc(C)nn1-c1ccccc1)C(=O)OCC |w:7.7|
Structure:
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