Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43534
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
23790±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43534
Synonyms:
MLS000692834 | N-[[(Z)-2-bromanyl-3-phenyl-prop-2-enylidene]amino]-4-methyl-5-oxidanylidene-1,4-dihydropyrazole-3-carboxamide | N-[[(Z)-2-bromo-3-phenyl-prop-2-enylidene]amino]-5-keto-4-methyl-2-pyrazoline-3-carboxamide | N-[[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-4-methyl-5-oxo-1,4-dihydropyrazole-3-carboxamide | SMR000285172 | cid_16195082
Type:
Small organic molecule
Emp. Form.:
C14H13BrN4O2
Mol. Mass.:
349.183
SMILES:
Cc1c([nH][nH]c1=O)C(=O)NN=CC(Br)=Cc1ccccc1 |w:10.10,14.15|
Structure:
Search PDB for entries with ligand similarity: