Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43542
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
9733±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43542
Synonyms:
MLS000760904 | N-[5-(diethylsulfamoyl)-2-(4-morpholinyl)phenyl]-2-(2-pyridinyl)-4-quinolinecarboxamide | N-[5-(diethylsulfamoyl)-2-morpholin-4-yl-phenyl]-2-pyridin-2-yl-quinoline-4-carboxamide | N-[5-(diethylsulfamoyl)-2-morpholin-4-ylphenyl]-2-pyridin-2-ylquinoline-4-carboxamide | N-[5-(diethylsulfamoyl)-2-morpholino-phenyl]-2-(2-pyridyl)cinchoninamide | SMR000372215 | cid_4829647
Type:
Small organic molecule
Emp. Form.:
C29H31N5O4S
Mol. Mass.:
545.653
SMILES:
CCN(CC)S(=O)(=O)c1ccc(N2CCOCC2)c(NC(=O)c2cc(nc3ccccc23)-c2ccccn2)c1
Structure:
Search PDB for entries with ligand similarity: