Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43543
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43543
Synonyms:
4-[3-(2-methylanilino)-2-[(2-methylanilino)-oxomethyl]-3-oxoprop-1-enyl]benzoic acid | 4-[3-(2-methylanilino)-2-[(2-methylphenyl)carbamoyl]-3-oxoprop-1-enyl]benzoic acid | 4-[3-[(2-methylphenyl)amino]-2-[(2-methylphenyl)carbamoyl]-3-oxidanylidene-prop-1-enyl]benzoic acid | 4-[3-keto-3-(o-toluidino)-2-(o-tolylcarbamoyl)prop-1-enyl]benzoic acid | MLS000774532 | SMR000372038 | cid_2424442
Type:
Small organic molecule
Emp. Form.:
C25H22N2O4
Mol. Mass.:
414.4532
SMILES:
[#6]-c1ccccc1-[#7]-[#6](=O)-[#6](=[#6]/c1ccc(cc1)-[#6](-[#8])=O)\[#6](=O)-[#7]-c1ccccc1-[#6]
Structure:
Search PDB for entries with ligand similarity: