Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM49000
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00669±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM49000
Synonyms:
4-Cyano-3-methyl-5-(2-thiophen-2-yl-acetylamino)-thiophene-2-carboxylic acid diethylamide | 4-cyano-N,N-diethyl-3-methyl-5-(2-thiophen-2-ylethanoylamino)thiophene-2-carboxamide | 4-cyano-N,N-diethyl-3-methyl-5-[(1-oxo-2-thiophen-2-ylethyl)amino]-2-thiophenecarboxamide | 4-cyano-N,N-diethyl-3-methyl-5-[(2-thiophen-2-ylacetyl)amino]thiophene-2-carboxamide | 4-cyano-N,N-diethyl-3-methyl-5-[[2-(2-thienyl)acetyl]amino]thiophene-2-carboxamide | MLS000029746 | SMR000011326 | cid_655690
Type:
Small organic molecule
Emp. Form.:
C17H19N3O2S2
Mol. Mass.:
361.482
SMILES:
CCN(CC)C(=O)c1sc(NC(=O)Cc2cccs2)c(C#N)c1C
Structure:
Search PDB for entries with ligand similarity: