Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM55483
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
50000±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM55483
Synonyms:
(8S)-N-(2-amino-2-keto-ethyl)-3-(3-nitrophenyl)-7-propionyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8S)-N-(2-amino-2-oxoethyl)-3-(3-nitrophenyl)-7-(1-oxopropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8S)-N-(2-amino-2-oxoethyl)-3-(3-nitrophenyl)-7-propanoyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8S)-N-(2-azanyl-2-oxidanylidene-ethyl)-3-(3-nitrophenyl)-7-propanoyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | MLS000561030 | SMR000155939 | cid_11958578
Type:
Small organic molecule
Emp. Form.:
C18H21N5O6
Mol. Mass.:
403.3892
SMILES:
CCC(=O)N1CC2(CC1C(=O)NCC(N)=O)C[C+]([N-]O2)c1cccc(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: