Reaction Details Report a problem with these data
Target
M17 leucyl aminopeptidase
Ligand
BDBM59631
Substrate
n/a
Meas. Tech.
Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)
IC50
1510±n/a nM
Citation
 PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay (2009)[AID] 
Target
Name:
M17 leucyl aminopeptidase
Synonyms:
leucine aminopeptidase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67834.32
Organism:
Plasmodium falciparum 3D7
Description:
gi_124809582
Residue:
605
Sequence:
MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKKNINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSKYADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL
  
Inhibitor
Name:
BDBM59631
Synonyms:
MLS000048432 | N-(2,3-dihydro-1H-inden-5-yl)-2-(4-oxidanylidene-1,2,3-benzotriazin-3-yl)ethanamide | N-(2,3-dihydro-1H-inden-5-yl)-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide | N-indan-5-yl-2-(4-keto-1,2,3-benzotriazin-3-yl)acetamide | SMR000065338 | cid_2695552
Type:
Small organic molecule
Emp. Form.:
C18H16N4O2
Mol. Mass.:
320.3452
SMILES:
O=C(Cn1nnc2ccccc2c1=O)Nc1ccc2CCCc2c1
Structure:
Search PDB for entries with ligand similarity: