Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM51786
Substrate
n/a
Meas. Tech.
uHTS absorbance assay for the identification of compounds that inhibit VHR1.
IC50
4900±n/a nM
Citation
 PubChem, PC uHTS absorbance assay for the identification of compounds that inhibit VHR1. PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM51786
Synonyms:
3-[((2Z)-5-[(acetyloxy)methyl]-3-{[(2,4-dimethoxyphenyl)amino]carbonyl}-8-methyl-2H-pyrano[2,3-c]pyridin-2-ylidene)amino]benzoic acid | 3-[[5-(acetoxymethyl)-3-[(2,4-dimethoxyphenyl)carbamoyl]-8-methyl-pyrano[2,3-c]pyridin-2-ylidene]amino]benzoic acid | 3-[[5-(acetyloxymethyl)-3-[(2,4-dimethoxyanilino)-oxomethyl]-8-methyl-2-pyrano[2,3-c]pyridinylidene]amino]benzoic acid | 3-[[5-(acetyloxymethyl)-3-[(2,4-dimethoxyphenyl)carbamoyl]-8-methyl-pyrano[2,3-c]pyridin-2-ylidene]amino]benzoic acid | 3-[[5-(acetyloxymethyl)-3-[(2,4-dimethoxyphenyl)carbamoyl]-8-methylpyrano[2,3-c]pyridin-2-ylidene]amino]benzoic acid | MLS001201165 | SMR000564168 | cid_4413344
Type:
Small organic molecule
Emp. Form.:
C28H25N3O8
Mol. Mass.:
531.5134
SMILES:
COc1ccc(NC(=O)c2cc3c(COC(C)=O)cnc(C)c3o\c2=N/c2cccc(c2)C(O)=O)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: