Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61276
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
41305±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61276
Synonyms:
3-[(4-chlorobenzyl)amino]-5-(2-furyl)cyclohex-2-en-1-one | 3-[(4-chlorophenyl)methylamino]-5-(2-furanyl)-1-cyclohex-2-enone | 3-[(4-chlorophenyl)methylamino]-5-(furan-2-yl)cyclohex-2-en-1-one | MLS000110196 | SMR000106127 | cid_2887097
Type:
Small organic molecule
Emp. Form.:
C17H16ClNO2
Mol. Mass.:
301.767
SMILES:
Clc1ccc(CNC2=CC(=O)CC(C2)c2ccco2)cc1 |t:7|
Structure:
Search PDB for entries with ligand similarity: