Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM58989
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
72240±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM58989
Synonyms:
MLS000374613 | N-(2-chloranyl-5-morpholin-4-ylsulfonyl-phenyl)-2-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanamide | N-(2-chloro-5-morpholin-4-ylsulfonylphenyl)-2-[4-(4-hydroxyphenyl)piperazin-1-yl]acetamide | N-(2-chloro-5-morpholinosulfonyl-phenyl)-2-[4-(4-hydroxyphenyl)piperazino]acetamide | N-[2-chloro-5-(4-morpholinylsulfonyl)phenyl]-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamide | SMR000244228 | cid_4373523
Type:
Small organic molecule
Emp. Form.:
C22H27ClN4O5S
Mol. Mass.:
494.992
SMILES:
Oc1ccc(cc1)N1CCN(CC(=O)Nc2cc(ccc2Cl)S(=O)(=O)N2CCOCC2)CC1
Structure:
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