Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM53722
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM53722
Synonyms:
2-(2-tert-butyl-4-keto-quinazolin-3-yl)isoindoline-1,3-quinone | 2-(2-tert-butyl-4-oxidanylidene-quinazolin-3-yl)isoindole-1,3-dione | 2-(2-tert-butyl-4-oxo-3(4H)-quinazolinyl)-1H-isoindole-1,3(2H)-dione | 2-(2-tert-butyl-4-oxo-3-quinazolinyl)isoindole-1,3-dione | 2-(2-tert-butyl-4-oxoquinazolin-3-yl)isoindole-1,3-dione | MLS000550102 | SMR000113994 | cid_828511
Type:
Small organic molecule
Emp. Form.:
C20H17N3O3
Mol. Mass.:
347.3673
SMILES:
CC(C)(C)c1nc2ccccc2c(=O)n1N1C(=O)c2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: