Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63398
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63398
Synonyms:
2-methyl-4-[4-(4-morpholinylmethyl)-2-thiophenyl]-5-oxo-N-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide | 2-methyl-4-[4-(morpholin-4-ylmethyl)thien-2-yl]-5-oxo-N-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide | 2-methyl-4-[4-(morpholin-4-ylmethyl)thiophen-2-yl]-5-oxidanylidene-N-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide | 2-methyl-4-[4-(morpholin-4-ylmethyl)thiophen-2-yl]-5-oxo-N-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide | 5-keto-2-methyl-4-[4-(morpholinomethyl)-2-thienyl]-N-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide | MLS000729321 | SMR000307599 | cid_5295485
Type:
Small organic molecule
Emp. Form.:
C26H29N3O3S
Mol. Mass.:
463.592
SMILES:
CC1=C(C(C2C(=O)CCCC2=N1)c1cc(CN2CCOCC2)cs1)C(=O)Nc1ccccc1 |c:11,t:1|
Structure:
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