Reaction Details Report a problem with these data
Target
Vacuolar aminopeptidase 1
Ligand
BDBM50895
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits
EC50
26760±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
Vacuolar aminopeptidase 1
Synonyms:
AMPL_YEAST | APE1 | API | LAP4 | YSC1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57084.90
Organism:
Baker's yeast
Description:
gi_486173
Residue:
514
Sequence:
MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
  
Inhibitor
Name:
BDBM50895
Synonyms:
(4Z)-4-[[5-(2,5-dichlorophenyl)-2-furanyl]methylidene]-3-methyl-5-isoxazolone | (4Z)-4-[[5-(2,5-dichlorophenyl)-2-furyl]methylene]-3-methyl-2-isoxazolin-5-one | (4Z)-4-[[5-(2,5-dichlorophenyl)furan-2-yl]methylidene]-3-methyl-1,2-oxazol-5-one | (4Z)-4-[[5-[2,5-bis(chloranyl)phenyl]furan-2-yl]methylidene]-3-methyl-1,2-oxazol-5-one | 4-{[5-(2,5-dichlorophenyl)-2-furyl]methylene}-3-methyl-5(4H)-isoxazolone | MLS000534352 | SMR000141784 | cid_5733602
Type:
Small organic molecule
Emp. Form.:
C15H9Cl2NO3
Mol. Mass.:
322.143
SMILES:
CC1=NOC(=O)\C1=C/c1ccc(o1)-c1cc(Cl)ccc1Cl |t:1|
Structure:
Search PDB for entries with ligand similarity: