Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67309
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
11200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67309
Synonyms:
1-(4-chlorophenyl)-3-(2-phenothiazin-10-ylethanoylamino)thiourea | 1-(4-chlorophenyl)-3-[(2-phenothiazin-10-ylacetyl)amino]thiourea | 1-(4-chlorophenyl)-3-[[1-oxo-2-(10-phenothiazinyl)ethyl]amino]thiourea | MLS000860546 | N-(4-chlorophenyl)-2-[2-(10H-phenothiazin-10-yl)acetyl]-1-hydrazinecarbothioamide | SMR000458630 | cid_2813686
Type:
Small organic molecule
Emp. Form.:
C21H17ClN4OS2
Mol. Mass.:
440.969
SMILES:
Clc1ccc(NC(=S)NNC(=O)CN2c3ccccc3Sc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: