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Target
Tumor necrosis factor
Ligand
BDBM67413
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3
IC50
19900±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM67413
Synonyms:
2-(4-fluoranyl-3-methyl-phenyl)sulfonyl-5-(4-methoxyphenyl)pyrazol-3-amine | 2-(4-fluoro-3-methylphenyl)sulfonyl-5-(4-methoxyphenyl)-3-pyrazolamine | 2-(4-fluoro-3-methylphenyl)sulfonyl-5-(4-methoxyphenyl)pyrazol-3-amine | MLS-0435774.0001 | [2-(4-fluoro-3-methyl-phenyl)sulfonyl-5-(4-methoxyphenyl)pyrazol-3-yl]amine | cid_20873617
Type:
Small organic molecule
Emp. Form.:
C17H16FN3O3S
Mol. Mass.:
361.391
SMILES:
COc1ccc(cc1)-c1cc(N)n(n1)S(=O)(=O)c1ccc(F)c(C)c1
Structure:
Search PDB for entries with ligand similarity: