Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM69203
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity
EC50
>300000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM69203
Synonyms:
2-[4-(dimethylamino)-1-pyridin-1-iumyl]-1-(10-phenothiazinyl)ethanone;chloride | 2-[4-(dimethylamino)pyridin-1-ium-1-yl]-1-phenothiazin-10-yl-ethanone;chloride | 2-[4-(dimethylamino)pyridin-1-ium-1-yl]-1-phenothiazin-10-ylethanone;chloride | MLS000689071 | SMR000283191 | cid_16192708
Type:
Small organic molecule
Emp. Form.:
C21H20N3OS
Mol. Mass.:
362.467
SMILES:
C[N+](C)=c1ccn(CC(=O)N2c3ccccc3Sc3ccccc23)cc1 |(7.44,13.06,;6.14,12.3,;4.83,13.06,;6.14,10.79,;7.44,10.04,;7.44,8.53,;6.14,7.78,;6.14,6.27,;4.83,5.51,;3.52,6.27,;4.83,4,;3.52,3.25,;2.18,4.06,;.81,3.28,;.81,1.71,;2.18,.94,;3.52,1.74,;4.83,.99,;6.14,1.74,;7.49,.94,;8.85,1.71,;8.85,3.28,;7.49,4.06,;6.14,3.25,;4.83,8.53,;4.83,10.04,)|
Structure:
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