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Target
Importin subunit alpha-1
Ligand
BDBM75011
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
136400±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75011
Synonyms:
MLS000419438 | N'-(1,3-dimethyl-2,6-dioxo-4-pyrimidinyl)-1-naphthalenecarbohydrazide | N'-(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)naphthalene-1-carbohydrazide | N'-(2,6-diketo-1,3-dimethyl-pyrimidin-4-yl)naphthalene-1-carbohydrazide | N'-[1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-4-yl]naphthalene-1-carbohydrazide | SMR000320236 | cid_2145327
Type:
Small organic molecule
Emp. Form.:
C17H16N4O3
Mol. Mass.:
324.3339
SMILES:
Cn1c(NNC(=O)c2cccc3ccccc23)cc(=O)n(C)c1=O
Structure:
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